Coronary Artery Disease – New Insights and Novel Approaches

This monograph deals with the pathophysiology of atherosclerosis with emphasis on epigenetics, metabolomics, inflammation, molecular and cellular mechanisms involved in cardiovascular disease development. This book has been written with the intention of providing new concepts about coronary artery disease pathogenesis that may link various aspects of the disease, going beyond the traditional risk factors.

Contents

Preface

Part 1 Pathogenesis

1 Gene Polymorphism and Coronary Heart Disease

2 Lipoprotein(a) Oxidation, Autoimmune and Atherosclerosis

3 ICAM-1: Contribution to Vascular Inflammation and Early Atherosclerosis

4 Molecular and Cellular Aspects of Atherosclerosis: Emerging Roles of TRPC Channels

5 Hypoxia-Regulated Pro- and Anti-Angiogenesis in the Heart

6 Paraoxonase 1 (PON 1) Activity, Polymorphisms and Coronary Artery Disease

Part 2 Acute Coronary Syndrome

7 Acute Coronary Syndrome: Pathological Findings by Means of Electron Microscopy, Advance Imaging in Cardiology

8 Shortened Activated Partial Thromboplastin Time (APTT): A Simple but Important Marker of Hypercoagulable State During Acute Coronary Event

Part 3 Cardiovascular Prevention

9 Individualized Cardiovascular Risk Assessment

10 Metabolomics in Cardiovascular Disease: Towards Clinical Application

11 Novel Regulators of Low-Density Lipoprotein Receptor and Circulating LDL-C for the Prevention and Treatment of Coronary Artery Disease

12 Serum Choline Plasmalogen is a Reliable Biomarker for Atherogenic Status

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